Studies on the Pathogenesis of the Generalized Shwartzman Reaction

Summary

Autoprothrombin-C (factor Xa) was given intravenously to rabbits whose RES had been previously blocked with thorotrast. The coagulo-analytical results as well as the morphological changes resemble those of the classical generalized Shwartzman reaction (gSr) produced by properly spaced doses of Gram-negative endotoxin. The results are discussed in the light of the literature.

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